Effect of exercise intervention on plasma levels of lipids molecular species in the elderly.

Kawanishi Noriaki, Yokozeki Kyosuke,
Kato Yuki, Sawada Shuji, Takahashi Masaki,
Sakurai Ryota, Fujiwara Yoshinori,
Shinkai Shoji, Goda Nobuhito,
○Suzuki Katsuhiko

 The disruption of lipid metabolic pathways by aging plays important roles in disease such as diabetes, arteriosclerosis, and neural degenerative disorders. On the other hand, it is shown that chronic exercise may prevent and/or dampen the development of these diseases, but this evidence is not sufficient. Lipidomics has provided an evidence to pinpoint specific lipid molecular species and its association with diseases. Previously, we examined the effects of aging of the lipid molecular species in serum by using lipidomics analysis. Triacylglycerol: TAG (52:3), TAG (52:4), Ester-linked phosphatidylcholine (PC), and ester-linked phosphatidylethano -lamine (PE) levels in serum were significantly higher in elderly subjects when compared to young subjects. Ether-linked PC and ether-linked PE were higher in elderly subjects when compared to young subjects. In this study, we aimed to clarify the effects of exercise intervention on the lipid molecular species in plasma of the elderly. Interestingly, TAG (52:3), TAG (52:4), and TAG (54:4) were reduced by exercise intervention. Moreover, ester-linked PC, and ester-linked PE were reduced by 3 months of exercise intervention. In contrast, ether-linked PC and ether-linked PE were not changed by the exercise intervention. These results suggest that some lipid molecular species may be selectively changed by the effect of chronic exercise. Our findings suggest that these lipid molecular species can be used as an indicator of aging.